When a murder occurs on an ocean liner docked in New York, the trail leads to Coney Island and a spy ring.

A murder is committed during the auction of a valuable statue. The prime suspect is Boston Blackie, whose reputation for living on the edge of the law makes him an easy target for the police. When the body disappears, Blackie must find it to prove his innocence.

It is the Christmas Holidays and reformed thief, Boston Blackie goes to Castle Theater to pick up players who will perform for prisoners that are still in prison. He takes a girl with him who has a brother already in prison. She has visited the prison twice in the month, so is not suppose to visit again. However when the group is completed the girl is included as well as Inspector Farrady. One of the clowns in the show is kidnapped and replaced by a con who wants to get even with two ex-partners. Boston Blackie figures out that a con has replaced one of his clowns but is unable to stop him. Blackie's clothes are stolen and a murder is committed. Of course, the Inspector immediately suspects Blackie of being involved. Now it is Blackie's job to find the killer, exonerate himself and help the girl free her brother.

Blackie receives a call from a friend who asks him to retrieve some money from his apartment and deliver it to him in California. Performing this good deed, he is accused of theft, but is allowed to proceed to Hollywood to help the police find a lost diamond.

Blackie is arrested when retrieving stolen gems from a safety deposit box for a friend.

A mad scramble for stolen loot ensues after Boston Blackie has prisoners released for work in a wartime defence plant.

After a rare gem is stolen from an exhibition at a posh hotel, Inspector Farraday decides to recruit former thief Boston Blackie to find the stone. Along with his assistant, "The Runt", Blackie focuses his investigation on the hotel manager, George Daley, and his sister, Eileen. Through disguises and ruses, Blackie and the Runt try to trick their way to discovering the thieves.

Blackie is implicated in a murder when he accidently sells a phony Charles Dickens first edition at an auction.

Blackie helps the police rescue hostage from an escaped maniac on a killing spree.

Blackie runs into a woman he formally loved who now is married with a kid. When her husband gets out of prison he's killed in Blackie's apartment and of course the police thing Blackie pulled the trigger. Blackie must set out to prove his innocence as well as capture the real killers.

Boston Blackie, in the 11th film of the Columbia series, indulges in some wit-trading with a squirmy spiritualist who deals in blackmail, murder and the occult. "Blackie" out to help his pal, "Runt," recover some jewels, finds himself involved in the homicides, and also finds himself as the prime suspect, and now has to find the real culprit in order to clear himself. So "Blackie,", a man of many talents and already a proved magician from cases past, shows he knows a little bit about dancing skeletons, walking phantoms and spiritualism himself, and holds a séance to unmask the murderer.

Blackie performs in a magic show at a women's prison, which gives an inmate an opportunity to escape.

Blackie is the natural suspect when an expensive pearl necklace is stolen while he is supposed to be guarding it.

Blackie is seen leaving a Chinese laundry where the proprietor has been murdered, and must track down the real killer in Chinatown.