While on her honeymoon, WWII combat nurse Claire Randall is mysteriously transported back to 1743 Scotland, where she is kidnapped by a group of Highlanders - and meets an injured young man named Jamie.
Claire decides to use her medical skills to aid her escape from Castle Leoch - with Jamie's help, she tends to an ill child. During an evening's entertainment, a story gives Claire hope for her freedom.
Claire joins the MacKenzie rent-collecting trip. To her horror, Dougal uses Jamie's scars to gain sympathy for the Jacobite cause. Claire recalls that a defining moment in Scottish history is fast approaching.
Claire and Jamie are thrown together in marriage, but as their emotional and physical relationship unfolds, deeper feelings arise. Claire is ultimately torn between two men in two very different times.
Jamie finds himself between a rock and a hard place when a redcoat deserter from his past resurfaces. Claire tends to a laboring Jenny while Jamie and Ian join The Watch, resulting in devastating consequences.
Claire and Jenny set out to rescue Jamie from his redcoat captors. When Murtagh joins up, they turn to unorthodox tactics to send word to Jamie. When word finally arrives, the news isn't what anyone had hoped.