When $10 million is stolen from the safe of a newly constructed, computer controlled building, the thieves program the computer to lock down the building. Spider-Man must free the occupants and catch the thieves.

During the theft of some NATO defense plans at the airport, Julie Masters inadvertently takes a picture of one of the thieves. When they go after Julie, Spider-Man must protect her while trying to recover the stolen plans.

After being released from prison, an ex-politician breaks out his partners and try to steal $100 million.

A widow is haunted by the spirit of her late husband, who tells her to donate his estate to a private organization which investigates paranormal phenomenon. Jameson, being a friend of the family and knowing Parker is a graduate student in physics, asks Parker to investigate.

Parker suspects he is being used to frame an innocent person when he develops an incriminating photograph he didn't take. He is then jailed for contempt when he doesn't turn the photo over to the police.

When a Sorgenson Chemical representative discovers a mind control drug works, he uses it on the students developing it.

In order to keep his job, Min Lo Chan, China's Minister of Industrial Development, ventures to America in search of three U. S. Marines that can clear his name. Standing in his way is a wealthy American industrialist whose plans for a large steel contract hinge on Chan's failure.