Sam and Dean follow the coordinates left in their father's journal and land in the middle of the woods where they investigate the disappearance of several campers. The two brothers soon learn they are dealing with a Wendigo, a creature made famous in Native America legends. A Wendigo is a former human whose cannibalism has transformed him into a creature with superhuman strength and speed that feasts on human flesh.

After the fight between Jake and Sam, Dean has to make the ultimate sacrifice for his brother. Meanwhile the Yellow-Eyed Demon has his new servant and plans to unleash the hordes of Hell.

"I'll Kill her gentle." The angels want Anna dead, so Sam and Dean go on the run with the frightened girl, determined to discover the secret that has set the furies of Heaven on her.

Super fan Becky uses Chuck’s phone to trick Sam and Dean into attending a Supernatural fan convention, complete with fans dressed up as Sam and Dean. One of the activities is a live action role playing game, but things quickly turn sour after a real ghost appears on the scene.

The showdown between good and evil is at hand. With the Apocalypse looming, Sam and Dean realize they are out of options and make heart-breaking decisions that will change their lives forever. A beloved character faces death.