Ghost Busters meets Dukes of Hazard boys in a Boys Own fun romp. That's how I'd describe the enormously successful series, Supernatural.
This is not one to test the synapses but more a lightweight but entertaining monster mash up. The hero's of the piece Sam and Dean Winchester are kick ass hunters who track down and kill monsters and various other supernatural nasties.
This series sounds formulaic and indeed it is but it manages to be creative enough with its stories, introducing new plot lines and characters to keep things reasonably fresh. No small feat after 14 seasons.