Sam and Dean investigate the murder of a lawyer and his wife, who claimed to have seen a ghost before they were killed. However, local authorities arrest the Winchesters after looking into their past.

Sam and Dean allow themselves to be arrested in order to investigate a series of murders inside a penitentiary. However things get complicated when FBI agent Henricksen shows up to take over their case.

A young girl trapped in a coma by her wicked stepmother sets off a series of murders based on the fairy tales her father reads her. Meanwhile, Sam tries to get Dean out of his deal.

Can torture be God's work? After seven angels are mysteriously murdered, Castiel and Uriel demand that Dean use the agony-inducing skills he learned in Hell to extract information from Alastair.

Familiar plot. Familiar characters. Sam and Dean come across a series of graphic novels called "Supernatural" featuring two demon-hunting brothers named Sam and Dean.

Castiel helps Sam and Dean hunt down Cupid on Valentine's Day after townspeople start to kill each other for love. However, after Cupid tells them he's innocent, they discover Famine, one of the Four Horsemen of the Apocalypse, has arrived in town.

Dean seeks out Death to help get Sam's soul back. Death tells Dean he will help Sam if Dean will agree to act as Death for 24 hours. Meanwhile, Sam decides he doesn't want his soul back and asks Balthazar for a protective spell to keep his soul out of his body. Balthazar tells Sam he needs the blood of his father for the spell to work and since John Winchester is dead, Sam decides Bobby is the next best thing.

Eve, the Mother of All, unleashes a new monster upon the world: a black worm-slug that can enter the brain and force people to kill. Sam and Dean join forces with Bobby and Rufus and track it to a cannery, only to discover that Gwen and Samuel are also there looking for the monster... and none of them know who the monster is inside.

Sam and Dean investigate the gruesome murders of resident mediums in Lily Dale, the most “psychic” town in America. They discover that an angry spirit is killing off the psychics one by one, but in a town full of people who claim to be summoning spirits, they have a little trouble identifying the medium controlling the ghost.

Sam and Dean investigate strange happenings in a town where childhood fears are coming to life. To Sam's horror his childhood fear of clowns manifests in a very violent and traumatic way which in turn leads to Dean's childhood fear, losing his brother.