Sam and Dean begin to explore what Jack is capable of doing with his powers. An unexpected visit from Donatello alerts the boys to the fact that Jack will need more protection than the Winchesters can provide. There is a new Prince of Hell in town, Asmodeus, and with Lucifer out of the picture, he sets his sights set on Jack.

As Sam and Dean continue their search for Jack, with Asmodeus hot on their trail, they stumble across a familiar foe. Meanwhile, Lucifer manages to escape Michael’s grasp and finds himself an unlikely and mostly unwilling ally.

Sam, Dean and Castiel search for Lucifer who, meanwhile, strikes an unlikely deal with a local faith healer named Sister Jo. Asmodeus inches closer to finding Jack.

Sam and Dean continue to collect the pieces necessary to open a rift to the other world in order to save their family. Their latest quest leads them to a Men of Letters bunker from the 1920s and a hungry God from another dimension. Meanwhile, Ketch makes a shocking decision about Gabriel after an unruly encounter with Asmodeus.

Lucifer rules over heaven but things aren’t going exactly as planned, exasperating his first lady, Jo. Sam and Castiel are perplexed by the return of Gabriel. Meanwhile, Dean gets one step closer to finding Mary and Jack.