Sally Fairfax is a personal assistant to the smarmy philandering Harvey Stafford. Her devotion is severely tested when she returns to the office late one night and finds herself party to a murder.

Ms. Kate Marshall (Dawn French), a brilliant surgeon, tries to murder the wife of a former patient who died when the woman confronts her with accusations that she was negligent during surgery. Kate runs the woman over with her vehicle... several times. As luck would have it, the woman doesn't die and is brought to St. Theodore's as a victim. Kate also has a television show and the case becomes a prime topic on the show, much to Kate's dismay.

When Daisy Talwinning, an abattoir worker sacked because she can't bring herself to kill the cute animals, goes on holiday to Panador in South America, she gets caught up in a case of mistaken identity, just as a rebel leader is about to be executed - the officials think she is the executioner.

When former gangland boss Frank Foster is brought in for questioning about the murder of a policeman, he's interrogated by Sgt Hodge and Sgt Cole, both intent on promotion.

The Angel of Death, who is a not-very-Grim Reaper, is given a deadly ultimatum: deliver some souls or be sentenced to a life in Hell.