A day shift takes an unexpected turn for West Midlands Ambulance Service paramedics, Nat and Nat, when a 999 call about an unconscious patient suddenly becomes very personal. In the meantime, a 19-year-old girl has been taken ill at school.

New Year's Eve is the busiest shift of the year for West Midlands Ambulance Service. Extra staff is brought in to care for those in need, but the night does not go as planned.

Pete and Matt, a specialist trauma team, are called to treat the victim of a brutal knife attack. Paramedics Christine and Chris start their day shift with a man who has collapsed in Worcester town centre after a suspected drug overdose. Jo and Tracey are called to 90-year-old Dennis, who's been vomiting. Christine and Chris are dispatched to Theresa, a terminally ill patient with suspected neutropenic sepsis caused by her cancer treatment. Crewmates Mark and Nieaal drive 20 minutes on blue lights to Ledbury in the dead of night to treat 96-year-old Jim.

Nina and Lauren respond to a caller whose mother has stopped breathing and is in cardiac arrest. The call handler in the control centre gives CPR advice over the phone while paramedics travel on blue lights to the scene.

At the start of a night shift, West Midlands Ambulance Service is receiving a High volume of emergency calls and is struggling to cope. A specialist paramedic attends a machete attack but his less urgent jobs are even more time-consuming.