After Jimmy Pritchard is killed in a robbery at his son's home, Pritchard is brought back to life in the body of a younger man by a billionaire and a bioengineer.

Due to the power surge that Mary and Otto caused in bringing Pritchard back to life, two notorious murderers escape from prison. Still determined that this is his city to protect, Pritchard goes on the hunt for them, and Mary - who believes she's partially responsible for the fugitives' escape - offers assistance.

Jimmy attempts to prove that he was a better police officer and man than Duval ever realized. A deadly psycho and another father-son duo cause problems.

A former case ends up becoming relevant as Pritchard and Duval take a look into some murders involving young prodigies.

Pritchard and Duval attempt to catch a killer who mutilates and disfigures victims.

Pritchard needs to try and hide his history with Wally, who is now dating his daughter, Helen, after it is discovered that Wally is being coerced by a prisoner planning an escape.

An important drug dealer is responsible for a murder 20 years before, which Pritchard helped to cover up.

Pritchard and Duval team up to chase a serial killer. Meanwhile, Mary and Pritchard's bond grows stronger, but Otto wants to make sure she'll always be by his side; and Gracie tries to get to the bottom of Pritchard's identity.

Albert Lin's real identity and who created him present a dilemma for Pritchard and Duval, who also frantically search for Gracie after she goes missing. Meanwhile, Otto's relationship with Mary is strained by the investigation, and he mulls the risk of destroying everything they've built, including Pritchard, by siding with Connor Graff.

Gracie's life is in danger unless Pritchard and Duval can reach her in time and rescue her from Connor and Otto's experiment. Meanwhile, Mary and Alexa search for a way to save Pritchard since he can no longer regenerate in the tank; and Otto struggles to come to grips with his decisions that have touched so many lives.