April goes on a joyride with Leo before starting her treatment, and manages to gain insight into his recklessness and the severity of his illness.

April goes to see a fertility doctor before beginning chemotherapy and also seeks advice from her support group about how to reveal her illness to Dominic.

April takes a day off from work to hang out with Beth and people from her support group, and she finds out something surprising about Leo. Brenna goes on a class trip to Miami.

When Beth hosts a house party, April lets loose – a little too loose – which leads to a major blowout with her friend. The new school year finds Brenna feeling alone and bullied. Meanwhile, Leo gets some valuable advice from Sara and ends up getting a job, but he finds the new experience more challenging than he expected.

April panics about a recent recurrence of her cancer symptoms and her worries increase about the stability of her remission. A desperate search for ways to alleviate her anxiety leads her down unexpected paths. The tension between April and Leo is still palpable, but a twist of fate may encourage them to reconnect. Meanwhile, Sara hosts a college prep meeting for other parents and students from Brenna’s school, and Brenna becomes increasingly annoyed by the pressure of Sara's expectations and worries for her academic future. Beth’s job is taking up all of her time, which has repercussions in her personal life.

April has a weekend getaway with Beth in Bermuda, but it's not the carefree trip they envisioned. Elsewhere, Sara faces some financial troubles; and Brenna finds a sense of belonging at Charton.

As the wedding date draws near, April is forced to face a list of “lasts,” such as her last week of living at home and her last time being a single girl. While her natural instincts are to have a classy and low-key bachelorette party, Vanessa helps April realize that this might be her last time to live it up. Another possible “last” opportunity presents itself for April when Dominic sets up a meeting for April with his book agent. With her health still in question, this opportunity may be April’s first (and last) chance to get a book published.

After a shocking traumatic event, April is left reeling and is flung into a world of grief.

April uses her new financial security to do anything and everything she can do feel good again.