April gets a new assignment at work and reports to a new supervisor, Raquel. Sarah urges Brenna to get an after-school job to learn more about responsibility.

April learns that Dominic has a reputation; Sara introduces her new boyfriend to the family.

April and Dominic share family secrets with one another when they visit a psychic. George has a official diagnosis for April, whilst Sara feels she is been ignored.

April goes on a joyride with Leo before starting her treatment, and manages to gain insight into his recklessness and the severity of his illness.

April tries to remain in control of her life, despite having to check herself into chemo. Brenna tries splitting her time between Kieran and Greer.

April's chemo treatments begin to take a toll on her. Dominic realizes how much she has changed when he returns.

When Beth hosts a house party, April lets loose – a little too loose – which leads to a major blowout with her friend. The new school year finds Brenna feeling alone and bullied. Meanwhile, Leo gets some valuable advice from Sara and ends up getting a job, but he finds the new experience more challenging than he expected.

April gets some welcome news from Dr. Hamburg that bodes well for both her and Leo. At work, she gets wind of a possible story opportunity with baseball player Richie Miranda, but when she gets a bigger scoop than she bargained for, she is faced with a tough moral choice.

April panics about a recent recurrence of her cancer symptoms and her worries increase about the stability of her remission. A desperate search for ways to alleviate her anxiety leads her down unexpected paths. The tension between April and Leo is still palpable, but a twist of fate may encourage them to reconnect. Meanwhile, Sara hosts a college prep meeting for other parents and students from Brenna’s school, and Brenna becomes increasingly annoyed by the pressure of Sara's expectations and worries for her academic future. Beth’s job is taking up all of her time, which has repercussions in her personal life.

April has a weekend getaway with Beth in Bermuda, but it's not the carefree trip they envisioned. Elsewhere, Sara faces some financial troubles; and Brenna finds a sense of belonging at Charton.

Standing in April's shadow, Brenna stifles her true feelings as she leaves Charton and turns to Natalie for support. Dominic attempts to rebuild a relationship with his mom. April goes wedding-dress shopping.

As the wedding date draws near, April is forced to face a list of “lasts,” such as her last week of living at home and her last time being a single girl. While her natural instincts are to have a classy and low-key bachelorette party, Vanessa helps April realize that this might be her last time to live it up. Another possible “last” opportunity presents itself for April when Dominic sets up a meeting for April with his book agent. With her health still in question, this opportunity may be April’s first (and last) chance to get a book published.

It is the day they have all been waiting for – April and Leo’s wedding day.