A 1.ª temporada de Masters of Sex estreou a 29 setembro 2013.

Em 1956, a ex-cantora de boate e mãe solteira Virginia Johnson torna-se assistente do renomado OBGYN William Masters. Eles embarcam em seu estudo pioneiro sobre a sexualidade humana enquanto tentam navegar em seus sentimentos pessoais um pelo outro. A esposa de Masters, Libby, tenta conceber um filho para salvar seu casamento. Dr. Ethan Haas se irrita sob a supervisão do Dr. Masters e lida com uma sociedade em mudança. O reitor da universidade, Barton Scully, luta para apoiar seu protegido William Masters enquanto lida com um segredo pessoal de longa data.

A 2.ª temporada de Masters of Sex estreou a 13 julho 2014.

Dr. William Masters and Virginia Johnson struggle to get their work back on track while taking their relationship to a much more intimate place. Libby flounders in a loveless marriage and turns to volunteering. Former prostitute Betty DiMello tries for the American dream and ends up working with Masters and Johnson. Dr. Austin Langham becomes the spokesman for a popular diet company and the boy toy to its aggressive founder.

A 3.ª temporada de Masters of Sex estreou a 12 julho 2015.

Welcome to the swinging sixties. Thrust into the spotlight by the publication of their controversial study, Dr. William Masters and Virginia Johnson find themselves the unlikely leaders of the sexual revolution. But as newfound fame and pressures mount, their relationship becomes twisted and tangled – putting the couple in a position that even they might not be able to handle.

A 4.ª temporada de Masters of Sex estreou a 11 setembro 2016.

The seventies are in full swing and sexual experimentation is all the rage. Masters and Johnson should be celebrating, but their clinic is in legal trouble, their personal lives are in tatters and their relationship is on the rocks.