While Liz and the Task Force track a notorious underground biohacker, Red initiates a strategy to extricate himself from a problematic position. Meanwhile, Cooper's integrity is tested with a difficult choice.

While Red and Dembe enlist Glen's help in stacking the jury to Red's advantage for his upcoming trial, the task force investigates a series of mysterious deaths resulting from weaponized insects.

The task force is drawn into the investigation of an old case that has gained notoriety due to a popular true crime podcast. Red visits Dom Wilkinson for help making a difficult decision. Ressler makes a discovery about Katarina Rostova's past.

Liz and the Task Force take on a cold case that may have some new victims. Meanwhile, Red tries to help a friend of Dembe who is in danger.

As the Task Force investigates a kidnapping executed by seemingly impossible abductors, Dembe lands in a perilous situation. Meanwhile, a recent health scare causes Red to think about a successor.