As the president's true plan comes into focus, Liz and the task force fight to avert disaster. Red meets in secret with a man who holds information about his past.

Liz and the Task Force investigate an infamous assassin who has a long history of weaponizing diseases, but has now turned to even more insidious activities. Meanwhile, Red and Dembe travel to Cuba in search of a lead, and Aram considers a new relationship. Elizabeth Bogush guest stars.

The Task Force investigates the unexplained disappearance and sudden re-emergence of a governor. Meanwhile, Red and Dembe surveil someone close to Katarina Rostova, as she inadvertently involves Agnes in an operation of her own.

Desperate for information about the whereabouts of a longtime friend, Red directs the Task Force to find a blacklister who specializes in untraceable money transfers. Meanwhile, Liz receives some disturbing news from her daughter Agnes.

Red and Liz investigate Orion Relocation Services, an organization that surreptitiously facilitates the disappearance and relocation of criminals. Meanwhile, Katarina delves into the memories of an old friend in order to get additional information about the Townsend Directive.

Red and the Task Force pay a visit to a former blacklister, as an explosive confrontation leads Liz to make a critical choice