Newt Call, the bounty hunter, returns to Lonesome Dove to find a town that is nothing like what he left after Hannah died. Everyone he once knew has changed as well as himself. Newt also deals with some angry feelings towards Mosby as he fights with the new town sheriff.

Mattie gets involved with a man from Mosby's past who has only murder on his mind.

Mosby finds himself stranded on his way to Curtis Wells, and ends up accompanying three prostitutes on a journey to Twyla's. Meanwhile, Austin takes charge of the town.

After Mattie kills the son of a local businessman in self-defense, Mosby has to decide whether his potential profit is more important than Mattie's friendship.

When Fiona turns up dead, Call has to prove himself innocent of her murder, but when Josiah seems to be the next best suspect, Austin is willing to convict Call to save his father.

When it comes time to bidding on the ownership of the Lonesome Dove, Mosby is shocked when he's outbid by Amanda Carpenter, a newcomer in town. Unfortunately, Amanda comes with a past of her own.

UnBob's son arrives in town after the death of his mother (Noleen Carmody) and starts trouble, and Call discovers there's been a bounty hunter placed on his head for a crime he didn't commit when he has to kill an old associate, Morgan Dibbs, in self-defense.

In order to 'prove himself' to Halcyon mines, Mosby ignores safety regulations in the Curtis Wells mine to make a profit. When an explosion results in numerous injuries and some fatalities, Clay tries to shift the blame, even though he feels guilty.

A troupe of carnival folk, old friends of Amanda's, come to town, and when the fat lady dies, it looks like the whole town is cursed.

Call must find an abducted mail order bride, and Mosby has to get a preacher out of town before he can de-corrupt the citizens.

Mattie falls in love with Tom Andrews, the new teacher in town, but he's hiding some dark secrets.

Call becomes ill when he is bitten by a rattlesnake and ends up being cared for by the beautiful and dangerous Enona, who is looking into her brother's death.

A series of mystery murders in town has everyone looking at everyone else, but Clay's lover Florie comes under particular suspicion, until she is attacked.

Call hires on to be the trail boss for a man who reneged on his deal to sell cattle to Mosby.

After Call and Mattie stop four men from conning Mattie in a gun deal, their leader Ned approaches Austin and manipulates him into going after Call.

A mysterious stranger saves Luther's life in a fight, and while Luther is willing to make friends, Call can't help but be suspicious.

A pair of teen lovers take Austin hostage and threaten to destroy Curtis Wells with a Gatling gun.

Arriving home late one evening, Mosby is beaten and robbed by three men, one of whom he believes lives in Curtis Wells. As the search for the culprit proceeds, the evidence points towards Austin. As Mosby strips Austin of his badge and plans to have him hung, Call takes off after the real guilty party at the urging of Josiah.

When Violet and Abraham Phillips are found dead in their home, their daughter Frances confesses to the crime, but Dr. Cleese isn't quite so sure she's guilty.

When respected shaman Little Wolf is murdered, Call has to prove to Red Crow that Enona, a mysterious female bounty hunter, did not do it.

After Amanda loses the hotel in a poker game, Clay wins it back for her, but there are strings attached. Mattie says goodbye to the men of Lonesome Dove as she prepares to move on with her life.