Jane McDermott is a 32-year-old former drug addict. She was convicted for murdering her father and is now serving a life sentence for the crime. She had always claimed to be innocent, and now the National Justice Project believe her and have taken her case.

Dan Wainwright had spent the past 13 years in prison for robbery and murder. Convinced he is innocent, his wife contacts the National Justice Project for help because she wants to clear her husband's name and introduce him to the son he never met.

A high school athlete was convicted of murdering a college girl eight years earlier. His sister contacts the National Justice Project for help because she believes her brother is innocent and this is her last hope.

The National Justice Project takes the case of a teenager who was convicted of murdering his own sister. Conti takes this case very personal because of a similar case he worked on when he was a police officer.

Donald Brooks was convicted for the murder of an unborn child in 1999, during a burglary and violent fight with the mother. A former jusro asks the National Justice Project to reopen the case because he now believes Brooks was railroaded.

Brianna and Sonya are working on the case of a woman convicted of murdering an elderly couple. Things get complicated when they learn of Swain's personal relationship with the former prosecutor for the case.

While investigating a case, Conti and Swain become suspicious and believe a federal informant is really a member of a far-right militia group who was involved in the bank robbery murder for which their client was convicted.

The National Justice Project takes the case of Frank Benner, a mildly retarded man, who was convicted of murdering a priest and sentenced to death.

The National Justice Project takes the case of a convicted rapist, but there is dissention in the team when some of the members side with the victim who is sure of her eyewitness testimony.

After receiving an anonymous tip with evidence of a taped confession of a bombing, the NJP reinvestigates a couple who have already been convicted of the crime.

Brianna becomes personally involved when she pleads the case for a man who is serving 30 years for stealing a case of vodka because it was his third strike.

When a murder case from Sonya's past re-emerges, the National Justice Project team's investigation leads them to San Diego and Mexico.