The team re-opens the 1989 case of an unidentified Jane Doe when she dies in the hospital, after being comatose since the day she was shot 18 year ago.

When a severed hand is discovered at the scene of a drug bust, the team re-opens the 1997 case of a convicted criminal who was thought to be on the run from authorities all these years.

The 1991 death of an inner-city schoolteacher is reinvestigated when new evidence indicates she may have been murdered instead of dying accidentally during a carjacking that got out of control.

When Dexter Collins, a young activist with a bright political future was found shot to death in 2005, it went down as a drug buy gone awry. Following a new tip regarding the location of the weapon, the police reopen the case and interview everyone from members of street gangs to his opponent for the city councilman seat.

The team has to cope with their own emotions as they search for the shooter responsible for Jeffries' shooting.

The 2004 murder of a teen at a juvenile detention center is investigated. The boy was wrongly sent to the facility and was killed before Valens could get him released. Meanwhile, Lilly reconnects with former flame Eddie Saccardo, a narcotics officer.

The 2005 murder of an Army recruiter who was killed just two days before his scheduled deployment to Iraq is reinvestigated after a soldier comes forward with new evidence.

After determining the serial killer's identity - and some of his likely future targets - the team and the FBI work together to apprehend him while trying to locate and protect the people he's preparing to kill.

Rush tries to ignore her father's appeals to give her troublemaker sister another chance after she suddenly resurfaces.