After their mother gets a new job, the Carlin family moves from small town Ohio to the big city of Los Angeles, California. Siblings Spencer, Glenn and adopted African American Clay must adjust to a new school, friends, and problems and must try and survive in a place where everyone else is also trying to find their identity.

After their mother gets a new job, the Carlin family moves from small town Ohio to the big city of Los Angeles, California. Siblings Spencer, Glenn and adopted African American Clay must adjust to a new school, friends, and problems and must try and survive in a place where everyone else is also trying to find their identity.

"Friends, Lovers, Brothers, and Others" was the technical second but chronological third episode of South of Nowhere that aired on November 11, 2005 on the teen drama channel, The-N.

Ashley is not too impressed with Spencer's new gal pal. Meanwhile, Clay finds common ground with someone he least expected and Madison puts Glen and Aiden in a possibly dangerous situation.

Ashley makes a video involving revelations of people's first time having sex. As Clay's first date with Chelsea nears, he is forced to face a lot of unwanted attention and even advice as everyone finds out he is still a virgin. Meanwhile, Ashley decides to get back at Madison and Sherry for spreading rumors about her.

Spencer and Ashley sneak out of the school while its under lockdown. While sneaking out, Spencer reveals her feelings towards girls, and Ashley tries to help but it hurts Spencer in the process.

Spencer and Ashley have a friendly competition for Aiden’s affection, which gets a little out of hand. Clay and Sean have a night from hell as they are on their way back from the movies. When two dead bodies come into the ER, Paula and Arthur are forced to deal with the harsh realities of living in Los Angeles.

Ashley makes a new friend named Josie, only to learn that Spencer doesn't approve. Clay's term paper makes him struggle with his identity, and Glen and Aiden arrange a wild poker.

Spencer accepts a date with Aiden, which ends up confusing her even more. Clay faces trouble while searcing for his birth mother, while Paula and Arthur try couple's counseling as a way to deal with their issues.

After nursing Ashley through a rough night, Ashley and Spencer are closer than ever. Meanwhile, Clay borrows Sean’s car and heads to Arizona for a personal mission and Glen is on a rollercoaster of his own, with some great news from a college recruiter… followed by an event that may change his life forever.