Joining scientist Benton Quest, his plucky son Jonny, bodyguard Race Bannon and Jonny's young pal Hadji are Benton's biologist wife Rachel, Race's ex-wife Jade and young 12-year-old Jessie, who harbors a big secret. Throughout, Team Quest battles the evil schemes of modern-day alchemist Dr. Zin, who has cloned himself and created an army of mutant reptiles in the Peruvian rain forest. The clash there results in a tragedy that changes Jonny's life forever - and later leads to a worldwide pursuit of Zin that includes examining rare Leonardo da Vinci documents in Paris, exploring the Roman catacombs and a final confrontation in the Australian outback.

The evil Dr. Zin has genetically modified household pests into disturbingly large insects that he calls assassinoids, fearless and devoted warriors that will carry out his plan for world domination. Team Quest, headed by internationally respected scientist Benton Quest, is Earth's only hope. When the good doctor becomes Zin's captive, the stakes - and the action quotient - grow higher. Enter Jonny Quest, Dr. Quest's bright, excitable, imaginative and heroic young son, ex-special agent Race Bannon, Jonny's child genius pals Hadji and Jessie (Race's daughter), their robotic pal 4-DAC and bulldog Bandit to complete the job of vermin extermination before it's too late.