Bonnie and Lois take a little trip to Paris where Bonnie crosses the line.

When Brian discovers that Carter Pewterschmidt’s pharmaceutical company is withholding the cure for cancer from the public in order to gain more profit, he and Stewie plot to expose the big secret that could change the world. Meanwhile, Quagmire reveals a hair-raising secret of his own.

Chris leaves home to move in with Herbert while Stewie and Brian become obsessed with singer Anne Murray.

Peter is convinced that a restaurant placemat is a treasure map. Word quickly spreads about the alleged cache, sparking a city-wide search and turning the citizens of Quahog against each other.

Peter helps Joe fulfill his dream of getting a book published, only to take over as the writer. In the meantime, Brian develops an extreme thirst for exercise.

When Peter’s couch is stolen from his front lawn, the guys form a neighborhood watch group. While on duty, Peter sees someone trying to climb into Cleveland’s house and he shoots him. Peter is then arrested and charged with a hate crime. Meanwhile, Cleveland is touched when Peter finally admits to the accident, so he takes the fall for the crime and Peter is exonerated.

When Chris' Mexican girlfriend, Isabella, gets deported, he volunteers to take care of her twin babies. After learning that Isabella can't come back to the U.S., the Griffins go to Mexico to return her children.

Peter encourages Meg to attend a high school party, where she takes up drinking, which both concerns and delights her father. Meanwhile, Brian begins spying on his neighbors and suspects Principal Shepherd of a crime.

After Peter's hair turns white from a ghost-hunting adventure in his house with the guys, his new look grabs the attention of local news anchor Tom Tucker. Under Tucker's guidance, he learns the ways of reporting fake news, and soon becomes a senior crime analyst on Quahog's Channel 5 News. Meanwhile, Brian and Stewie attempt to help Chris improve his dating game.

Meg plans her wedding to an unexpected Quahog resident. Meanwhile, Peter finds a new vest and on one of many adventures fitting for his new attire, his arms are torn off and he is left with tiny hands that have yet to grow back.

Meg deals with a college admissions scandal, while Brian embarks on a fitness journey.