The team discovers murder victims with the alien glyphs on them that Coulson's been etching. All of Coulson's secrets and lies come to a head.

As Robert Gonzales makes his move, Coulson must do whatever it takes to protect the future of S.H.I.E.L.D. Meanwhile Skye’s journey to control her powers takes a surprising turn when she meets the enigmatic Inhuman named Lincoln.

After her dramatic rescue from another planet, Simmons is still reeling from her ordeal and reveals how she had to fight for her life in a harsh new world.

Coulson and General Talbot are forced to team up and attend a worldwide symposium on Inhumans, where they suspect Malick has an inside man. As the S.H.I.E.L.D. team gets closer to the truth, an unexpected traitor is revealed.

With only two episodes left before S.H.I.E.L.D. loses one of their own, Daisy's prophecy ticks closer towards a major loss, as the aftermath of the events of Captain America: Civil War force S.H.I.E.L.D. to register the Inhumans.

As Coulson, Mack and Fitz attempt to track down and neutralize a rogue group looking to end Inhuman Registration worldwide, Simmons and Dr. Radcliffe only have hours to save May before she succumbs forever to her mysterious illness.

Agents Sam and Billy Koenig are hunted down to get at the Darkhold book, and only Phil Coulson and the team can save them before the clock ticks out.

With the surprising help of Lance Hunter, nothing will stop Fitz from finding the lost team as his incredible journey is revealed.

The team goes in search of Gravitonium in order to save the world.

Daisy's future as the Destroyer of Worlds could take a critical change.

It’s a wild night out on the planet of Kitson for the agents. While Leo and Enoch try their luck at the casino, nearby, Daisy and Simmons find themselves in a much... groovier situation.

To face The Galaxy-Hopping Hate-Beast That Eats Planets, the team on Earth asks for help in all the wrong places. While back on the Lazy Comet, something weird is going on with Izel’s crew, and it’s not just the puffies.

With the identity of the timeline-unraveling "thread" revealed, the team's mission to protect him at all costs leads each agent to question their own values. Is preserving the future of the world as they know it worth the destruction they could prevent?