The world turns against S.H.I.E.L.D. when HYDRA impersonates them to attack The United Nations, and an unexpected enemy leads the charge to bring about their downfall.

Coulson and the team search for the Inhuman who is killing other Inhumans. Meanwhile, May feels that Hunter's mission to take down Ward is getting too personal.

In the aftermath of his trip to Maveth, Coulson is more determined than ever to get to Gideon Malick and put an end to HYDRA once and for all. Daisy and the team encounter more Inhumans who have powers like they've never seen before, but will they be friends or enemies of S.H.I.E.L.D.?