In a collection of affluent suburban communities north of Atlanta called “The Heroin Triangle” the rise of the nation’s opioid crisis, from prescription pills to full-blown heroin epidemic, is documented through city officials, community leaders, and addicts themselves. Tiffany and Billy, a volatile couple living out of their car, receive a sizable tax return that sets them up to score a large of amount of heroin. Their addiction threatens to destroy the family they’re building. As a homeless and gay man, Tracey faces unique challenges as he spends his days hopping busses and hiding out in bathrooms stalls shooting heroin. Zac’s a free-spirit but his musical gifts are undermined by his crippling heroin addiction. Interventionist Heather Hayes enlists the help of her colleague Donna Chavous to further investigate the city’s handling of the epidemic.

23-year-old heroin addict Toni finds herself in danger when her pimp sends her out on a call that goes wrong. The Heroin Triangle expands its reach, putting first responders at risk, and increasing police presence in the area. Police Sergeant Josh Liedke reaches out to a young homeless addict and tries to get her into a detox center. 55-year-old Allen finds himself squatting in an abandoned house, having squandered millions from his trust fund to feed his heroin addiction.

Interventionist Michael Gonzales attempts to get Toni's mother, father, and sister on the same page to intervene on Toni, but Carla's belligerent behavior threatens to derail the process before it even begins. We meet Kiersten and David, a young, heroin-addicted couple living in a co-dependent relationship with David's mother, Linda. Kiersten prepares for a mandatory meeting with her probation officer by hiding synthetic urine in her boot, in case of a drug screening.

Ken Seeley and Allen's family try to convince him that treatment is the best option, but police are called to the scene when the situation escalates. 24-year old Taylor dances at a local strip club to finance her heroin habit. David and Kiersten's relationship comes to a dramatic head when David's mother loses her patience with Kiersten. 31-year old Angela quits heroin cold turkey, and is now "white knuckling" it through her day while trying to win back custody of her two children. Toni disappears and the search is on to find her before it's too late.

Ken Seeley and Allen’s family try to convince him that treatment is the best option, but police are called to the scene when the situation escalates. 24-year old Taylor dances at a local strip club to finance her heroin habit. David and Kiersten’s relationship comes to a dramatic head when David’s mother loses her patience with Kiersten. 31-year old Angela quits heroin cold turkey, and is now “white knuckling” it through her day while trying to win back custody of her two children. Toni disappears and the search is on to find her before it’s too late.

Taylor's mother makes a disturbing discovery; Angela's frustration with her ex-husband challenges her ability to stay clean; Kiersten attempts to reconcile with her parents, but her heroin use stands in the way.

Angela encounters a deadly relapse trigger; Taylor's mother has trouble keeping her emotions in check after her daughter's dangerous lifestyle escalates; Donna Chavous employs tough tactics in her double intervention of Kiersten and David.

David and Kiersten's intervention hits a roadblock when David changes his mind about getting help; Taylor endures a painful trip to the dentist, who deals with several infected teeth; reviewing the progress of Toni, Allen and Angela.