The friends reunite to turn what was once just a dream into a reality. As Ami and three world-class tattoo artists open up a tattoo shop in Miami's South Beach called Miami Ink, the four friends and apprentice Yoji, hope to build a thriving business.

As the business grows, the guys of Miami Ink struggle with the pressure of balancing their personal life and work

Ami and crew deal with changes and transformations in their lives and relationships, including the wedding of Yoji to his fiance Bridgette when they get married in a beautiful ceremony on the beach.

While the gang adjusts to the responsibility of owning their own business, a list of celebrity clientèle wait months for their turn under the needle with the masters.

Yoji slowly learns the ropes, but still has a way to go before he can tattoo. Also: a former member of rock band Skid Row gets tattooed with his kids' names.

Yoji and Brigette's daughter is born.

A medal-winning Paralympic athlete comes in to get his tribal tattoo completed. Meanwhile, Yoji and Bridgette bring Sydney to the shop to meet the others.

Darren Brass takes a little spill and breaks his elbow, so Ami brings in a new girl from Los Angeles to substitute for a few weeks.

While exercising to get into better physical shape, Ami revives an old back injury. Meanwhile, the gang are hesitant to let Yoji handle a solo tattoo job on a woman.

On a trip to Oahu, Hawaii, Ami James and Chris Garver meet Keoni Nunez who teaches them traditional Polynesian tattooing. Next, they sit in at a shop in Honolulu and tattoo six locals.

While they're in Hawaii, they also meet professional surfers who take them to catch some waves.

Trouble and confusion are brewing with the artists. They learn that as you get more money, you also get more problems. Ami buys his dream car and Darren puts his life and career on the line by drinking too much.

Yoji learns that he must show improvement in his drawing skills or Ami will remove him from his apprenticeship.

Nunez's partying starts to get in the way of his work and demeans the shop's reputation. Meanwhile, Ami spends time with his mother, who is visiting from Israel.

Tensions rise when Ami leaves town just as a huge storm is about to hit and leaves Chris Nunez in charge. Meanwhile, Darren tries to convince his wife to leave Connecticut and join him.

Kat makes a surprise visit from Los Angeles, delighting the overworked staff, and Ami tries to get past the memory of a past accident and resume rising a motorcycle.

Kat stays on and helps out while Ami and Chris are vacationing in Hawaii. Now under the temporary management of Nunez, the shop is kept busy doing an intricate Alphonse Mucha design for a breast-cancer survivor and a special tattoo for custom-motorcycle builder Billy Lane. Meanwhile, apprentice Yoji gets his first solo job for a paying customer.

Garver works on a guardian angel design while Ami finishes a Hindu-inspired piece and then undertakes a Hawaiian-themed design. However, with so much work to do, the long hours are getting to everyone.

Darren does an inspirational tattoo to honor a man's uncle, while Garver does one for a woman who has struggled for years to overcome an eating disorder. Yoji's long work hours are affecting his family life, and the gang offers to look after his daughter while he and his wife see a family therapist. Meanwhile, the guys are jealous of Nunez's lunch date, and Ami places a radio ad for a friend who is looking for a fiancee.

Darren's wife finally moves to Miami, forcing him to give up his notorious partying. Meanwhile, Yoji and Ami participate in a celebrity ping-pong tournament to benefit underprivileged kids.

Nunez gives a young girl the design of her dreams, then helps another with an image to keep her mother's memory alive. Meanwhile, Darren gives his father a first tattoo, and Garver places an image of the World Trade Center on a skateboarder.

Against Ami's wishes, Yoji gets a Mohawk haircut and adds a tattoo to his head. But Ami can't complain too much when apprentice Yoji finally gets his first paying client.

Ami does a rosary design for a girl in memory of her grandfather, Darren makes a design to remind a rock musician that you only live once, and Garver creates a skull tattoo.

Later, the guys temporarily leave the tattoo world and collaborate on paintings for an international art show.