In 1997, the frustrated wife of a multi-millionaire convinced her lesbian lover to kill her husband. Her fatal mistake was instead of embracing here partner in crime she ditched the Sapphic spouse slayer soon after the crime.

Virginia Larzelere's husband Norman was a successful Daytona Beach dentist, and they enjoyed a beautiful home, expensive cars, a yacht, and an airplane. But the good times came to an abrupt end on March 8, 1991, when a masked gunman broke into Norman's office and killed him with a shotgun blast to the chest.

Few smiles were brighter than those of two married dentists, who shared a thriving practice and a seemingly perfect marriage. But that changed in July of 2003, when the wife began to suspect her husband was having an affair with his secretary.

A bright and bubbly surgical technician led a comfortable middle-class existence with her husband. But this sunny, suburban image vanished in smoke and flame on Valentine's weekend of 1998 when they went on a romantic getaway meant to rekindle their marriage, at a golf resort on Maryland's Eastern Shore.

A woman who always had a thing for hunky men married a Long Island gym owner in 1998, and everyone thought it was the perfect match. She just had one small problem with her new husband - his crack cocaine addiction.

An over-achieving real estate developer and aspiring politician was the wife of a respected urologist in the upscale D.C. suburb of Potomac, MD. In 1994, she made a run to be the Republican nominee for the U.S. Senate, but lost, partly due to a local attorney who dogged the campaign with allegations of shady business deals. Soon after, her husband and the local attorney are murdered.

A 24-year-old young woman went from rags to riches when she met and married a Miami construction millionaire in 1981. Together, the couple lived lavishly in an exclusive Coconut Grove mansion, went skiing at their Steamboat Springs ranch, and partied all night long at Stan's Miami nightclub. Then one night, the pampered trophy wife's husband is killed in a home invasion robbery.

A middle-class Houston housewife married to a successful salesman, was a stay-at-home mom raising two adorable young children in their suburban home. But then, in January of 2003, he mysteriously disappeared.

Engaged high school sweethearts met in 1991 as volunteers in the Texas Civil Air Patrol. She was an honor roll student bound for Annapolis, and he was a track star with an appointment to the Air Force Academy. This former Navy cadet was just 19 when she learned he had cheated on her. Her rival ends up dead but who did it?

A spunky and ambitious toxicologist at the San Diego medical examiner's office was a summa cum laude graduate of San Diego State University. Her husband worked for an up-and-coming biotech firm. Well-educated, highly intelligent, and good-looking, their future seemed limitless. So why did the husband commit suicide, or did he?

The female bookkeeper and business manager of a millionaire Texan entrepreneur was also a close confidant of his wife. They were so close that he, and others, began to suspect that the pair were more than just friends. Then, the entrepreneur husband was poisoned.

A millionaire heiress landed a job teaching computer science where she met and began an illicit affair with a popular sixth grade teacher. Then, the married man's wife was murdered, but who committed such a brutal act?

Did twin sisters Peggy Lowe and Betty Wilson hire a hit man to kill Betty's husband, Dr. Jack Wilson? Could the hit man's testimony be believed?