Louise Simonson (born Mary Louise Alexander; born September 26, 1946) is an American comic book writer and editor. She is best known for her work on comic book titles such as Conan the Barbarian, Power Pack, X-Factor, New Mutants, Superman: The Man of Steel, and Steel. She is often referred to by the nickname "Weezie". Among the comic characters she co-created are Cable, Steel, Power Pack, Rictor, Doomsday and the X-Men villain Apocalypse.

In recognition of her contributions to comics, Comics Alliance listed Simonson as one of twelve women cartoonists deserving of lifetime achievement recognition.

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