聂万龙（秦沛饰）自败给石志康（陈庭威饰）后，已变得疯癫。石志康与妻子张嘉慧（万绮雯饰）也已退出赌坛。美洲赌王张天鼎（杨群饰）独当一面，称霸赌坛。其女张适茹（曾华倩饰）协助父亲打理美国赌场。张天鼎当年为求一己私利出卖洪氏两父子，使洪峰（吴毅将饰）含冤入狱。洪峰出狱后，即回 港劫走聂万龙助其复仇，誓要使张天鼎声名狼藉。张天鼎遂骗来石志康替自己出战。而张天鼎已暗中布下天罗地网，派手下狄信（吕颂贤饰）铲除康、峰二人。一场世纪之战旋即展开。

自從新一代無敵賭王石志康擊敗上代賭王聶萬龍後，賭霸張天鼎在美國成為獨當一面的美洲賭王。鼎有一獨生女適茹，協助鼎打理美國賭場。鼎當年為求一己私利出賣洪氏兩父子，使洪峰含冤入獄。龍被康擊敗後大受打擊，變得天真癡呆入住瘋人院，但賭技則更上一層樓，除已退隱的賭神高進外，幾近天下無敵，可能尤勝石志康…

Shek Chi Hong is now the number one "God of Gamblers" in the gambling world. He is a genius in gambling but prefers a quiet life. However, he can’t change his own destiny as long as he hasn’t retired from the gambling world. Knowing that Hung Fung's gambling skills have improved tremendously over the years, Cheung Tin Jing resorts to inviting Chi Hong to help him. Chi Hong refuses to step into the gambling world again due to the promise to his wife. It is not until Cheung Tin Jing fakes a heart attack that Ah Kong decides to help him finally. There, he meets Cheung Tin Jing's only daughter, Cheung Sik Yu and her childhood friend, Dik San. However, after his helping in Tin Ding winning over Mun Long, this in turn causes his wife's death. Since then, he becomes disillusioned in life.