Four siblings work as agents for the World Organization of Human Protection, otherwise known as WOOHP. Lee, Megan, Marc and Tony Clark all attend Southdale Junior High School and seem to be normal kids in every way -- except that they fight crime. Even their parents are unaware of the kids' unusual activities. Jerry Lewis, founder and chief of the organization, briefs the spies on their missions and doles out the gadgetry they'll need to take on evil.

Il s'agit de quatre jeunes agents secrets frères et soeurs: Tony, Marc, Lee et Megan, qui ont été choisis par le WOOHP pour devenir des espions internationaux. Ensemble, ils vont apprendre à jongler entre la vie quotidienne et l'espionnage.

Série de animação onde quatro irmãos: Lee, Marc, Megan e Tony Clark, estudantes da Escola Southdale, se tornaram espiões da WOOHP (Organização Mundial de Proteção Humana, em português). Comandados por Jerry, eles irão se envolver nas mais perigosas missões.