53岁的叶启华为家人鞠躬尽瘁，但家人却把他的付出当作理所当然，爱发梦的老婆朱莉也不曾把他摆在第一位。某天他发现自己身患顽疾，身心灵最脆弱的时候，家人连最基本的陪伴都无法给予，心寒的叶启华因此默默离家。他的好友马可隆经营一家健身中心，有强壮的体魄和帅气外形，堪称熟女杀手。直到某次意外导致脊椎受伤，外形上的衰弱和苍老彻底打垮他的自尊，陷入绝境……马可隆的老婆梁美美是精明能干的女强人，却因为没有大学文凭而被家婆Mary瞧不起，后来也因接受女儿的挑战，成为超龄的大学生。讽刺的是，原本对梁美美百般刁难的Mary在失智后态度大反转，把媳妇视为天使，却待亲生女儿马可晴为女佣。马可晴心甘情愿照顾失智母亲，从而养成依赖，母亲死后就迷失自己，后来在王七的帮助下走出阴霾。虽说这帮“五零高手”在人生前半段已经历不少风雨，但他们将如何以多年累积的智慧和经验迎接接下来的生命篇章？现实生活中的这帮演员，又怎么过接下来的半百人生？

Qi Hua, Wang Qi and Ke Long are childhood friends, although fast approaching their mid-fifties, they still kept the promise of cycling together to catch the sunrise on each other's birthday. Qi Hua is a doting husband and father who handles everything from household chores to bills. But that causes his wife and two children to be overly dependent on him. He becomes despondent with his family's neglect when he falls ill. What will he do to make them learn? Wang Qi is estranged from his son who blames the former for causing the death of his mother. Wang Qi may look unaffected but he has been secretly helping his son out whenever he can. Will his efforts win back his family? Ke Long is proud of his athletic body even at his age, but an injury makes him realizes that he cannot stay young forever, and his world starts to crumble. Does fifty really spells the end of a productive life? Or can these three friends press the restart button and turn their fifties into the new twenties?