While working as a gas station attendant in New Mexico, Kimble is taken hostage, along with customer Joanne, by two holdup men, named Miles and Vinnie. Once on the road, Kimble pretends that he is a criminal and is heading towards Los Angels for a ""big job."" At the same time, he lets Joanne know that he's on her side, but she's suspicious to his true motives. Once arriving in L.A., Kimble decides to set up Miles and Vinnie to be arrested. But Miles, not trusting Kimble enough, wants him to kill Joanne to prove himself.

While working as a dock worker in Florida, Kimble is recognized by Marcie King, a young woman whom five years earlier asked Kimble to perform an abortion for her (illegal at the time; pre-Roe Vs. Wade). Kimble refused due to his religious beliefs, and Marcie went to another second-rate doctor to have it done. But after the operation, because of complications, Marcie can no longer have children and she incredibly blames Kimble for it. When a hurricane hits the area, Marcie and her boyfriend Harry, an embezzler on the run from the law, approach Kimble and threaten to turn him in unless he drives them to safety from the hurricane and the police looking for them.

Kimble happens to watch a TV debate in which a once-renowned attorney, named G. Stanley Lazer, claims that he could reverse Kimble's criminal conviction if the case went back to trial. Lazer once a respected lawyer, had his license revoked after getting into a car accident years before while driving drunk in which his wife was killed. Lazer now spends his days teaching law at a small college in Harrisburg. Kimble travels to Pennsylvania and meets with Lazer and his assistant, Nancy Gilman, to enlist their help. To prove his theory, Lazer decides to conduct a mock trial with his students playing the prosecutor, defense lawyer, and jury in front of a live TV audience. But while the mock trial continues, Kimble becomes aware that Lazer is really putting himself on trial for his past misdeeds.

While hoping freight trains, Kimble meets a young woman named Carol Hollister with her baby whom she is traveling to meet her husband. But Kimble doesn't know that Carol is a mentally disturbed young woman whose newborn baby died a year earlier and she has abducted another baby. Soon, Carol becomes so far gone that she mistakes Kimble as her late husband. Kimble must find a way to get the baby away from Carol and return it to it's rightfull parents while avoiding the police looking for her.

Kimble finds himself working with Hallie, a woman who bears a strong resemblance to his late wife. Hallie knows of the resemblance, and Kimble's danger is increased when Hallie's husband becomes jealous.

Richard Kimble returns home when he learns his wife's family is in financial trouble. The complications are that his mother-in-law hates him, his sister-in-law loves him, and his father-in-law is being questioned by the police.

Barry Craft figures he'll get some publicity by arranging to have Kimble captured at his wild-animal show.

Kimble finds work at a Laundromat owned by Charlie Paris, a former stand-up comic and mob bookie who hopes to go straight. But Kimble doesn't know that that the underworld has put a hit contract on Charlie for testifying against some of their business ""associates."" Charlie hopes to make amends meet to his longtime girlfriend Paula, but she's more interested in Kimble. When a mob flunky offers Paula $8,000 for turning Charlie over to them, she does not pass up the chance and takes the money, while Charlie refuses to believe Kimble's suspicions that Paula plans to betray him.

This was the series finale. In the first part, the one-armed man whom Kimble has been pursuing has been arrested for a minor crime. Lt. Gerard tries to use this to lure Kimble out into the open. A woman who knows Kimble tries to help him. Kimble tries to see if this man is the one he is looking for but someone wires a bail bondsman some money to bail him out. KImble then visits the bail bondsman but finds him dead. He then goes through his papers and is shocked to see who sent the money. He then goes to see this person but Gerard catches and takes him in. As the one-armed man hops on a train, Kimble and Gerard are making their way back.

In the continuation of this story Kimble and Gerard are on a train for his hometown in Indiana. And Kimble then reveals that the person who sent the bail money is his brother-in-law Leonard Taft. Kimble doesn't think it was him but someone from his hometown did send the money and used his brother-in-law's name. The one armed-man calls the Tafts demanding that they meet with him, someone does go to the meeting but it's not Leonard Taft but the one-armed man assumes that he is, and says that he remebers him. Obviously this was the man who sent the money and the one-armed man is demanding more money which he doesn't have. Kimble and Gerard arrive at the Taft residence and talk to Len, who tells them that someone called claiming the same thing and arranged a meeting, Kimble ans Gerard arrive at the place and find some bullets. But for Gerard there is nothing more that can be done; they then go back to the Taft house so that Kimble can say good-bye to his sister, and it's at that moment tha