William Desmond, nascut William Mannion, va ser un actor nord-americà. Va aparèixer en més de 200 pel·lícules entre 1915 i 1948. Va ser sobrenomenat "El rei de les sèries silencioses".

Starting out in dramatic parts, Desmond soon switched to westerns and action serials, and became a major western star. When the sound era began Desmond was almost 50 years old, and was soon relegated to supporting roles.