The frustration and vital weariness of Michel des Assantes, a prestigious plastic surgeon in Paris, is unbearable: he has a wife whom he does not love, a son who is foreign to him and friends whom he despises but, at the same time, he is incapable of taking his own life. One day, he buys a bike from a bizarre cyclist who was to make the Paris-Timbuktu route and sets out to make the journey: then, Timbuktu becomes for him the Promised Land.

La frustración y el hastío vital de Michel des Assantes, un prestigioso cirujano plástico parisino, es insoportable: tiene una esposa a la que no ama, un hijo que le resulta ajeno y unos amigos a los que desprecia, pero es incapaz de quitarse la vida. Un día, le compra la bicicleta a un estrafalario ciclista que iba a hacer la ruta París­-Tombuctú y se lanza a hacer ese recorrido: Tombuctú se convierte para él en la Tierra Prometida.