Twenty-something and aimless, Joey Vitello still lives at home with his colorful Italian-American family when he is reunited with a childhood schoolmate, Mary O'Callahan. Once mocked as 'Scary Mary' this ugly duckling has blossomed into an irresistible beauty. She's returned to the old neighborhood after an intense bout with cancer. When Joey learns her cure was the result of a miracle, friendship turns to romance as she educates him on the crossroads to the Almighty. Joey challenges his family's faith with his new found revelations and chaos ensues as they all search for a miracle of their own.

Mary est de retour en ville et refait surface dans la vie de Joey. Ce qui a commencé comme un béguin d'écoliers pourrait devenir un amour éternel, si seulement amis et familles leur en laissent la chance.

Seine Liebe zur gläubigen Mary, die gerade von einer Krebserkrankung genesen ist, macht aus dem flatterhaften Joey einen besseren, gläubigen Menschen.

Mary torna in città e anche nella vita di Joey. Quella che era iniziata come una cotta alle superiori potrebbe diventare una storia d'amore che durerà per sempre, se solo amici e familiari dessero loro una possibilità.