Ren Xinzheng, a professor at the University of Traditional Chinese Medicine, is dedicated to spreading Chinese medicine. He resigned to set up a traditional Chinese medicine inheritance class, hoping to train successors who can truly pass on the way of Chinese medicine. Unscrupulous Sun Toutou also accidentally joined the mentoring class, and he was at odds with Ren Xinzheng's son Ren Tianzhen, Yang Xiaohong, who had changed his career as a lawyer, Peng Shiyan, a pediatrician at a tertiary hospital, and Zhao Liquan, who wanted to become a famous doctor with the expectation of the whole village, and other students were also incompatible.

Mare is an elementary school student. She lives with her family in the city, but, right before her father goes bankrupt, they run away and settle down at a fishing village in Noto. The family rents a couple's home who run a salt pond. Mare's father starts a new business, but it also fails. Her mother supports the family by working at the salt pond. 8 years later, Mare, about to graduate from high school, decides to work for the Wajima local government. She wants to have a steady job, unlike her father. Her job is to support people who move to Noto.

A sake brewery of long standing in Kanazawa is deep in the red. The owner’s only son Sagara Shuichi, an elite banker, resigns from the bank because of something that came up, and decides to stake his life on making sake. Grasping at straws, he clings to the legendary master brewer, Washio Yusaku. However, Yusaku is the man feared as an ogre. Shuichi is prepared to be “eaten by the ogre”, but he is thrust into a difficult position when he sinks further into debt because of Yusaku’s pursuit of “perfect sake making”. Moreover, the brewers working for Yusaku are strangers to sake making. They are men and women who have lost their places to go for their own reasons, and have moved in with the sake brewery. One of them is Shuichi’s cousin, Naoki. In the middle of preparing the daiginjo sake on which the fate of the sake brewery rests, an unusual and unpredicted change takes place before Naoki’s eyes. Will the sake brewery be turned around when the drops of liquid of their quest flow?