In this non-canonical entry in the Resident Evil/Biohazard franchise, five members of the U.B.C.S. are sent to Racoon City to trace Dr. Cameron and, foremost, her research. However, the horrors they encounter are beyond their imagination.

Picking up immediately after the events in Resident Evil: Retribution, Alice is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began - The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.

Two girls face a horde of zombies in the fictional city of Raccoon City.