"Palace of Serendipity" features award-winning actors and national treasures from the National Palace Museum. Ten award-winning actors and actresses creatively personify selected treasures with historical background and imagination. The personified treasures are residents in an apartment building that is isolated due to an accident. They each have their own short story and are subtly connected.

Two gold-digging brothers, Prawet and Jit, steal 117 pieces of treasure from the Dragon Cave. They both are attacked by a blood-sucking bat and they are cursed to be immortal. To remove this curse, they must return all treasures they stole to the cave. Prawet wants to do it, but Jit doesn't agree with his brother. This conflict causes these two brothers to be enemies. Later, both of their sons inherit their immortality.

One day, Jit killed Prawet by burning him. Traipoom, Prawet's son decides to follow his father's wish and tries to look for the lost treasures in order to take them back to the cave.