Since the graduation of the senior members of the club, Takezou ends up being the sole member of the "Koto" (traditional Japanese string instrument) club. Now that the new school year has begun, Takezou will have to seek out new members into the club, or the club will become terminated. Out of nowhere, a new member barges into the near-abandoned club room, demanding to join the club. How will Takezou be able to keep his club alive and deal with this rascal of a new member?

Sawamura Matsugorou is a shamisen player of legendary talent. Upon his death, his grandson, Sawamura Yuki, lost his ability to play. Having lost his beloved sound, Yuki finds himself in Tokyo in search of a new sound to love. Tachimura Yuna, who works at a club, hooks him up with a gig to play there as a warm up act. Yuki imbues the sound of his shamisen with his many thoughts and feelings he has of others, still searching for his own sound and his own feelings.

Lee Gyu Won is the daughter of one of the top three maestros of pansori and is also a gayageum protégé herself. Following her grandfather’s wishes for her to study the gayageum, she enrolls as a major of gugak, or traditional Korean music. Lee Shin is unfriendly, yet a clever student in the Applied Music Department who also is the famed vocalist and talented guitarist of the handsome band named The Stupid. With charming looks equal to those of a handsome character in a romance comic and a cold, taciturn personality, he thinks gugak is boring and belittles it. As the vocalist Lee Shin and Gayageum Protégé Lee Gyu Won passionately confront each other to champion their respective music, they soon fall in love.

Based on a webtoon of the same name, Jeong Nyeon is set in the 1950s and depicts the story of a young woman named Yoon Jeong Nyeon who grew up with nothing and learned nothing, but has the goal of becoming rich.