In 1750, an adulterous preacher is ejected from a small British colony with his motley crew of followers, who make their way downriver to establish a new settlement of their own beyond the western frontier.

In the wake of Hurricane Camille, the infamous '60's storm that crippled the Gulf Coast, a mysterious teenage girl washes up to shore, and the secrets of Mississippi's Sister Island crawl to the surface. Dorrie (Kathleen York), a young doctor living with her mother (Karen Black), assumes custody of the unknown girl (Erin Buchanan) and names her Camille. Terrified and unable to speak, Camille spends her days hiding underneath the dining room table. But when Dorrie unearths a series of curious circumstances surrounding Camille's past, a shocking mystery comes unraveled.

Over the course of a year a stoic drug dealer in south London forms an unexpected relationship with a buyer inside the safe sanctuary of his car.