Gerardo brings his mother's ashes to meet "the crazy woman" of the famous song of 'En el muelle de San Blas'. After thinking that she was dead, he finds Doña Berenice, who tells her story.

Mario confesses to his girlfriend Camila that he has HIV, she also gets infected. Camila's father wants her away from home, her mother saves her from suicide and she will seek to move forward with her life.

Pilar is secretly in love with her brother-in-law Toño, husband of her sister Erika. When Toño and Erika discover that they cannot have children, Pilar proposes to be the child's surrogate mother.

Fanny works as a waitress and her father wants her to be the girlfriend of Cristóbal, the son of a butcher shop owner, for which she will sabotage her relationship with Salvador, a migrant with whom she is in love with.

Silvana files for divorce from her manipulative husband and upon hearing this, her daughter faints. Silvana crashers her car with Jorge's car when taking her daughter to the hospital, who is captivated by her clear eyes.

Lupita suffers the recent wedding of her ex-boyfriend. Full of disappointment, she sings in a café bar where she is discovered by a judge of a singing reality show that catapults her to fame.

Julieta is an insecure girl who submits to Sebastián, a boy who thinks she is the love of his life, but who is actually a narcissistic psychopath never medically treated.

Teresa decides to file for divorce from her husband, the municipal president of Minatitlán, after one more of his infidelities. This will inadvertently take off her political career.

After seeing her sister to catch up, Pilar is sexually abused and beaten. Now she must overcome this hard experience and her husband's infidelity.

Zazil is a beautiful model who is successful in a major brand of bras, but surprisingly she finds out that she suffers from breast cancer and needs a mastectomy.

Ilse and Fabiola are two friends who fall in love with Miguel, a boy who sells records in a bazaar. After a misunderstanding, the friends distance themselves, but years later, their children will fall in love.

Karen is in love with her best friend Alexa with whom she prepares in fencing to qualify for the Pan American Games, but when Alexa starts dating Hugo, Karen cannot hide her jealousy.

Meli supports her sister Dalia in a lie that costs her life. Faced with Meli's femicide, Dalia seeks justice in front of a group of abusive and murderous juniors.

After being abandoned by her husband, Lorena meets Alex in her gym, a younger man to whom she offers a job and whom she falls in love with, but he will only take advantage of her.