Los Kent celebran el cumpleaños número 16 de los chicos y Lois recibe noticias sorprendentes.

Clark y Chrissy notan una pequeña grieta en la cara de juego de Lois; Sarah y Jordan tienen un encuentro incómodo; Lana recibe una llamada de pánico.

Lois y Chrissy buscan una nueva ventaja en la investigación de Mannheim contra los deseos de Clark. Mientras tanto, Jonathan, Jordan y Nat se enfrentan a un obstáculo inesperado.

Lois interrumpe una intensa conversación entre Clark y John Henry; Kyle intenta interponerse entre Sarah y Lana; Jonathan tiene una acalorada discusión con el padre de Candice.

Clark y el general Lane tienen dificultades para darle espacio a Lois para que tome sus propias decisiones; Lana y Sarah tienen un encuentro con un viejo amigo en el restaurante; Natalie tiene una visita sorpresa.

Lois and Clark dig deeper on Bruno Mannheim, starting with his connections to Hob's Bay Medical Center, while Jonathan and Jordan panic at home over Lois' dire diagnosis. Meanwhile, Matteo comes to Smallville to meet John Henry for the first time, and Sarah and Chrissy start to break the ice.

In the wake of learning that Bruno and Peia are married, Clark works to reignite Lois' interest in taking Bruno down. Elsewhere, Natalie meets Matteo's parents for the first time, with disastrous consequences. Meanwhile, the Kent boys clash when Jordan interferes with Jonathan's training at the Firehouse, Lana bonds with General Lane over their shared fear of dating again, and Sarah realizes her mom needs a friend.

Superman and John Henry clash over how to handle Bruno Mannheim, while Lois worries over upcoming treatments and confides in Lana about her early courtship with Clark. Meanwhile, Jonathan, Jordan, and Sarah work together to help Natalie deal with the aftermath of meeting Matteo's family.

Lois attempts to interview Peia in the hopes of unearthing the truth about an old case, while Clarke struggles to spend quality time with the boys. Meanwhile, Jonathan and Jordan find themselves at a party, where tensions between Sarah and Jordan come to a head. As Kyle's suspicions about a local meta-human grow, Lana must juggle her personal life with a visit from the governor. Finally, Matteo makes a life-altering decision.

Clark helps Lois prepare for a procedure but must leave the boys with her to help John Henry and General Lane track down the Mannheims. Meanwhile, John Henry and Nat butt heads over her desire to help Matteo, and Bruno's plans go awry as Peia's condition worsens.

Lois and Clark clash with Jordan over his carelessness around using his powers in public, while Jonathan struggles with Kyle's change in behavior at the firehouse. Meanwhile, Sarah grows frustrated with Lana after she accidentally makes things more complicated with Jordan. And finally, after seventeen years behind bars, Lex Luthor is set to be released from prison.

All of Smallville comes together to view a meteor shower, Lex Luthor makes his move.