Jess LaCroix and his elite team of FBI Fugitive Task Force agents track a doctor who's deeply involved in a world of organized crime, drugs and lies, and is on the run after a phone call records him delivering his wife's fatal shot.

Barnes goes on a dangerous undercover mission involving an ambitious gang leader who is plotting turf wars and massacres across the Bronx in a bid for more power.

When a military veteran suffering from PTSS snaps after the death of his brother in arms, the decorated sniper’s expert abilities push the team to their limits. Also, Crosby’s personal struggles bubble to the surface when the case begins to hit too close to home.

A cult leader and his most trusted followers go on the run after he orders the murder of his own family. As Jess and the team race to find them, they uncover the self-proclaimed prophet’s conman past.

After the disappearance of his daughter is ignored by local police, a Native American man decides to take matters into his own hands. When his search escalates to murder, the team must track him down before his crusade claims any more lives.

When a domineering man and his girlfriend embark on a terrifying multi-state killing spree, the team races to find a pattern behind the deranged couple's seemingly random acts of extreme violence. Also, Jess worries he's being left out of Tali's life when he finds out his daughter has already won an award at school.

After taking down a terrorist, the FBI and their Fugitive Task Force partners turn their attention to the terrorist’s wife who escaped with one million dollars and is determined to follow through with her husband’s deadly plan. Also, LaCroix’s daughter, Tali, is taken away by ICE, but as Jess tracks her down, he realizes her detainment may be more than just random coincidence.

The crossover starts on FBI S02E18 American Dreams (I).

With COVID-19 devastating the country, two gunmen take out their desperation and rage on the elite class they perceive to be oppressing them; Jess' father returns and may not be over his old ways.