After a young mother's death in 1988 goes unsolved, her older sister promises to solve the crime, no matter how long it takes, so she sets about on a quest for answers to determine who killed the victim in her own home and why.

Landlord Bruce Blackwood disappears without a trace in March 2006. Though there is no body, the NYPD is sure this is a homicide and they, along with Bruce's brother Ed, spend the next 9 years searching for answers and a killer.

In September 1974 in Ohio, 15-year-old Lori Nesson disappeared while walking home from a high school football game after-party. Her naked body is found in a ditch the next day yet is ruled undetermined natural causes. The search for her killer finally begins when the cause of death is changed to homicide 40 years later.

A fire in January 2007 in Canton, OH, claims the life of WWII vet Bennie Angelo; a closer look at the crime scene reveals Bennie was dead before the fire, bumping an arson case up to homicide.

When a 30-year-old mother fails to report for duty in Virginia, the Army lists her as AWOL. Her family immediately suspect foul play. They embark on a 13-year quest for answers before an eyewitness blows the case wide open.