In a parody of the Harry Potter series, Grim sends Billy and Mandy to a sorcery school so the latter duo could avoid boring summer camps they were supposed to go to. The sorcery school is owned by Dean Toadblatt, an anthropomorphic frog. Billy and Mandy are sent to the most hated house on the school, Weaselthorpe, while Grim becomes a prefect for a more loved house, Gunderstank. Billy and Mandy team up with boy wizard Nigel Planter to sabotage Gunderstank. Planter takes all the credit for the sabotage (which was Mandy's idea), but he is punished once he is found out by Toadblatt.

Billy and Mandy take a reluctant Grim to school with them. Mandy's nemesis, Mindy, befriends Grim to annoy Mandy, and Billy calls for their other friend, who is Abraham Lincoln. Mandy devises a plan in which Mindy ditches Grim, and keeps Abraham as her friend instead.

After watching Billy and Irwin play with their "Hokey Monsters" cards (parodying the Pokémon Trading Card Game), Grim makes the monsters come to life. Soon, all the other kids want their own cards to be real too, and the city is soon under attack by a multitude of Hokey Monsters. To put an end to the mayhem, Mandy draws her own card, Mandy's Monster, which defeats all the other monsters by turning them into toast.

Grim is lying sick in bed with "Encroaching Doom Syndrome". The Underworld doctors are not able to help Grim, and he becomes a human being. Back in Endsville, Grim seems attractive to women, but he ends up being punched by jealous boyfriends, especially Billy's dad Harold. Grim covers himself in the mucus that he produced when he was sick and becomes a skeleton again, and Billy tries it too.

Taking inspiration from his Pat the Baker video game, Billy decides to bake chocolate brownies. Billy uses "Evil Powder" from Grim's old trunk instead of salt, and the resultant brownies stink. Mandy tells Grim to get rid of the brownies, and he reluctantly does, but he also stores some of them in his skull. Soon, the stench of the brownies spreads through the world and starts resurrecting dead people, animals, and even food, as zombies.

Billy and Hoss Delgado, spectral exterminator, team up to destroy all the zombies that congregate outside the house, but the zombies reassemble into a bigger zombie. Delgado realizes that the zombie is after the brownies that Grim has in his skull, so Delgado and Grim battle furiously for them. The zombie eats the remaining brownies and falls apart.

On a hot day when Billy, Mandy, and Irwin are bored, Grim uses a crystal ball to show them the future. In the distant future, Mandy has turned herself into a giant worm-like creature to be immortal, and now rules the whole world. Mandy gives false information to a clone of Billy to capture the members of a resistance that try to defeat her. The episode parodies the science fiction novel God Emperor of Dune by Frank Herbert.

Billy accidentally sets off a powerful stink bomb in Mandy's house and, while the house is being disinfected and fumigated, Mandy's family goes to live with Billy's. Billy and Mandy have a dispute over how to split Billy's room, prompting Grim to intervene. Mandy takes over the entire room, and imprisons Billy inside a brick wall with his mouth gagged by a dark red handkerchief.

After excluding Mandy from their board game Who Killed Who? for being a girl, Billy and Irwin mistakenly throw their dice into the backyard of a haunted house. Grim warns them about the ghost of Mrs. Doolin, a lady that lived there. Mandy dares to go inside to retrieve the dice, and she befriends Mrs. Doolin, who is alive and well, and who says that all the stories told about her (that anything that went beyond her fence into her garden never came back) are inventions from Grim, whom she beat long time ago at a staring contest. Fearing for Mandy's life, Billy also ventures into the house, but Mrs. Doolin and Mandy scare him away by posing as ghosts. It appears that Mrs. Doolin is in fact a ghost, and when she meant "beating Grim", it meant that she "beaten death".

After Grim fails to pull a werewolf out of his hat, Irwin is bitten by said werewolf. Billy takes Irwin as his new pet dog, naming him Sprinkles, and enters him in the Endsville Dog Show to compete against Mandy's dog, Saliva. At the contest, Sprinkles is about to win, so Grim releases a "were-flea" whose bite causes the werewolf to revert to a naked Irwin. It appears that Irwin won the contest anyway.

When Billy, Mandy and Grim go to the beach, Grim falls in love with a goth woman named Malaria. Grim is having a good time with his girlfriend, but Mandy assures him that will change when he tells her that he is not human. In the following date, Grim demonstrates his supernatural powers while dancing and, as predicted, Malaria leaves in panic.

At school, Mandy rejects Irwin's invitation to go to the school dance with him. Billy introduces his foreign and mysterious, new friend, "Piff", and Mandy becomes desperate when she realizes that she has developed a crush on him. Mandy asks Grim to cut her heart out to stop being in love, but Grim has a better idea and gives Mandy a makeover. Piff gets a crush on Mandy, who takes the opportunity to brutally turn him down.

It's Valentine's Day and Nergal, the fiend living in Earth's core, appears in Billy's house to court Billy's spinster aunt Sis. Billy tries ruining Nergal's date, to avoid becoming his nephew. Although initially Sis does not show interest in Nergal, she changes her mind when Nergal is stung by bees and she sees his "dance moves". Aunt Sis accepts Nergal's marriage proposal and accompanies him back to the center of the Earth.

Billy takes a big egg found in Grim's trunk and hatches it expecting a duck. Instead, Jeff the Spider is born, who considers Billy his father. Despite Jeff trying to please Billy in any possible way, Billy is terrified of Jeff and wants him squished. The exterminator chose not to squish Jeff because he is a nice bug.

Billy is worried about failing an upcoming Math test, so Grim gives him a "bookworm", which will make him much smarter. Milkshakes, Billy's cat, eats the worm instead, and is forced to tutor Billy. Billy is still an idiot in the end.

Grim is upset after his favorite show, Atrocia's Late Night Atrocities, is cancelled. He goes to the TV station and using his powers, turns the studio into a creepier place and becomes the host of the Grim Show. Grim's success on TV is interrupted when Mandy tells him he has neglected to do her chores. Billy and Mandy go to the TV station and show embarrassing footage of Grim at home.

Billy and Mandy are sent to "Winter Camp", where they meet Nergal's son, Nergal Jr. Just like his father, Junior tries making friends, although not in the best way possible. Junior attacks the campers, freezes them and, using his shape-shifting abilities, takes over their appearances. Billy decides to be Junior's friend, but he is scared away at the moment Junior shows him his true form.

After being accidentally hit by Billy, Grim lands in a can of white paint in a remote convent. Due to his appearance, still with the can in his head, Grim is mistaken for "Sister Big Mamma" by little nuns. Grim has a great time with the friendly nuns, until Billy and Mandy come looking for him. When the nuns realize the truth about Grim they get angry at him, but also help him go back home by sending him flying away with another punch.

When Billy and Irwin exclude Mandy and Grim from helping them build a go-kart to enter the Annual Endsville Go-Kart Competition, the latter two decide to build their own. Billy-Irwin, and Mandy-Grim compete against Mindy, Sperg, and a mystery racer (Pud'n). Mindy gets stuck in highway traffic, Billy-Irwin's car is destroyed, Sperg and Grim mutually prevent each other from winning, and Pud'n wins in his little red wagon.

After being impressed by Irwin's realistic armor at the medieval fair, Billy wishes for a fancy armor too. Grim gives him the "Cursed Suit of the Black Knight". When Billy needs to go to the bathroom, the curse is revealed to be that the armor cannot be taken off until the person wearing it beats someone in a competition. Billy desperately tries to defeat other people at various contests, he but fails to come out victorious. He defeats Mandy at a breakdance contest in which Mandy decided not to participate, but he does not need to go to the bathroom anymore.

Billy wants to join Sperg's garage band, "Purple Filth", and take part in the upcoming battle of the bands. After witnessing Grim's prowess with the electric guitar, Sperg invites Grim instead. Billy's dad, adopting the rock and roll persona of "Mogar", decides he and Billy should go to the contest to make a surprise appearance. Billy impresses the audience with his armpit sounds.

After missing on a school trip, Grim takes Billy, Mandy and Irwin to the "Halls of Time" for a tour. There, Billy and Irwin mess the hourglasses that symbolize each person's lifespan. When they leave, they accidentally leave their own hourglasses, including Grim's, upside down, resulting in the group getting younger as time passes. Grim allows the kids to disappear by going before birth, but he cannot restore his own hourglass to its correct position and he disappears too.

After a lousy night for Grim, Billy and Grim argue about who has the hardest time, the kid or the Reaper of Souls. Mandy proposes they switch places for the day to find out. Grim seems to be having a good time, acting like a silly kid, while Billy is bored waiting for his old victim, Mr. Voorhees, to open the door. Billy transforms into a short skeleton, while Grim transforms into a taller version of Billy.

Grim's refusal to help Mandy win a karate tournament, and the $50,000 prize it promises to the winner, leads her to a curio shop, where the shopkeeper, Kuan Ti, gives her an ancient "Chicken Ball" which, when eaten, allows her to become a great fighter. Mandy easily wins the tournament and does not care about the money anymore, only about fighting. It turns out Kuan Ti is actually Eris in disguise, and this was just another of her schemes to create chaos. Seeing how he has a chance to get rid of the kids and finally be free, he tries to take advantage over this by making Billy a superb fighter too, so he and Mandy can fight ferociously to the death until the entire arena is destroyed. With both still alive, Mandy still demands the prize money, which she uses to buy Hector Con Carne's Bunny Island.

Billy, Mandy and Grim go trick-or-treating for Halloween, and Irwin is left behind because he needs a scarier costume. After pulling a trick on an old lady, and getting some candies, Grim tells the story of why people pull pranks, which he was partially responsible for.