Noah, Ethan, Jack and New Michael, better known as the comedy troupe Asperger's Are Us, prepare for a challenging six-week tour across the U.S. After shopping for the right set of wheels and mentally preparing for a journey that will challenge their ability to deal with change, they kick off their tour in Boston, performing for an enthusiastic hometown crowd.

The troupe arrives in New York City, where they perform at the legendary comedy venue, Caroline's in the heart of Times Square. In contrast to the success they have in Boston, the show proves difficult, with some of their routines falling flat, and the troupe leaves town questioning whether the tour was a good idea. After tackling the first of many RV woes, they arrive in Baltimore, where the guys chat with a journalist before taking the stage, hoping for a better outcome.

Noah, Ethan, Jack and New Michael spend the night at an RV park before dealing with unexpected audience feedback in North Carolina. After New Michael celebrates his love of a musical idol at a special event, the guys take to the stage in Tennessee, where New Michael vexes the others when he decides to drink during the show.

The troupe sightsees in Chicago before travelling to Ohio to perform a challenging show in Cincinnati that quickly spins out of control, leaving Noah frustrated with New Michael. Noah returns to his hometown of Dayton, Ohio where he reflects on his childhood, and the guys do a show that promises to get them back on track.

With a week of the tour left to go, Ethan begins to doubt himself and the purpose of Asperger's Are Us' cross-country journey. Facing their worst RV issues yet, the guys fight to make it on time to a show in Seattle, where Noah's dad is due to be in attendance.