Mary Jane is being stalked by her former boyfriend, Morris Bench, who's undergone an accidental metamorphosis and become Hydro-Man. Sweeping Mary Jane off her feet in a wave of water he insists she will love him. Spider-Man is nearly beaten by the semi-liquid culprit but with a little help from Mary Jane puts a stop to this villain by causing him to evaporate once drawn away from the water that feeds him.

Spider-Man and Venom must put aside their differences and help Iron Man stop Carnage and Baron Mordo from releasing Dormammu.

Ex-employee of Stark Industries, Dr. Jonathan Ohn, invents a portable interdimensional technology that accidentally makes him the living embodiment of a portal. Calling himself the Spot, he tries to steal money to fund his research. But his unstable invention has created a vortex that threatens to engulf New York. How can Spider-Man fight that?

Peter Parker and Mary Jane are finally a couple, but there happiness is short-lived as the Green Goblin, armed with a time distorter and the true identity of Spider-Man, seeks to destroy Spidey, by any means necessary.

Mary Jane and Peter arrive in Niagara Falls for their postponed honeymoon, but it is soon interrupted when Hydro-Man returns and kidnaps MJ!

Spider-Man finds himself in yet another dimension, where he meets .... himself!