Stała obsada sezonu 8

1. 

   Christopher Daniel Barnes

   Peter Parker / Spider-Man (voice)

2. 

   Sara Ballantine

   Mary Jane Watson (voice)

3. 

   Jennifer Hale

   Felicia Hardy (voice)

4. 

   Linda Gary

   Aunt May Parker (voice)

5. 

   Gary Imhoff

   Harry Osborn (voice)

6. 

   Ed Asner

   J. Jonah Jameson (voice)

7. 

   Rodney Saulsberry

   Joe "Robbie" Robertson (voice)

8. 

   Roscoe Lee Browne

   Kingpin (voice)

Goście specjalni 6

1. 

   Nita Talbot

   Anastasia Hardy (voice)

2. 

   John Phillip Law

   John Hardesky / The Cat (voice)

3. 

   David Hayter

   Brace Huntington (voice)

4. 

   Jack Angel

   Nick Fury (voice)

5. 

   David Warner

   Landon (voice)

6. 

   Efrem Zimbalist Jr.

   Doctor Octopus (voice)

Ekipa 3