A space shuttle piloted by J.J.'s son, John Jameson, crash lands on the Tri-Borough Bridge carrying two strange meteors -- One that could provide a new nuclear fuel and one that contains an alien substance. The first is stolen by the Kingpin's henchman, the Rhino, just as Spider-Man arrives to save Jameson and the co-pilots. When the Rhino sends the aircraft off the bridge, Spider-Man emerges from the water with a dark stain covering his costume. Exhausted, he heads for home, only to awaken hanging from a skyscraper, now clothed in a black version of his costume.

Morbius attempts to use the Neogenic Recombinator to turn everyone else into a vampire. Spider-Man and Blade try to stop him, and Morbius' mutation worsens. Morbius kidnaps Felicia Hardy in order to transform her into a vampire.

Tired of Jameson giving Spider-Man the rap for all the crime in New York, Peter decides to give up the superhero business once and for all, until he meets his biggest fan, a little girl named Tyina. Can she get Spidey to change his mind?

Spider-Man loses his memory and becomes partners in crime with Dr. Octopus. Can a little girl and a cabbie save him?

Spider-Man captures a gang of thieves, and it looks like Robbie Robertson is their leader! Peter Parker and J. Jonah Jameson must team up to try to clear Robbie's name. But while Jameson returns to the skills he had as an Investigative Reporter, Peter must keep him safe from Tombstone. At the bottom of the whole plot is Richard Fisk, but can Spidey find the right clues to clear Robbie in time?

When a savage creature begins attacking people in New York, Black Cat tries to convince Spider-Man that he needs her help to stop it. All clues point to the creature being Kraven The Hunter, but sleuthing by Debra Whitman, Flash Thompson, and the Black Cat solves the case. The beast, Calypso, is related to Kraven, but the Hunter wants to capture and cure her.

There's a new Vampire in town, but Morbius is getting all the blame. Just as Spidey, Black Cat, Whistler and Morbius have the Vampire Queen trapped, Blade bursts in and prevents her destruction. His revelation sets the others against him, while the queen attempts to create an army of vampires. Meanwhile, Harry Osborn discovers Peter's spare Spider-Man mask!

Peter and MJ's big day arrives, but things aren't going to go to plan if Harry Osborn gets his way. With guests including Flash Thompson, Liz, Aunt May, Anna Watson, Felicia Hardy, J. Jonah Jameson, Robbie Robertson and Wilson Fisk!? Along with gate crashers including the Green Goblin, the Kingpin, Alistair Smythe, the Scorpion, the Black Cat, Herbert Landon, the Mega-Slayer, Norman Osborn, and an army of robot Goblin Warriors, it'll certainly be a day to remember!

Peter is shocked by MJ's new powers so they seek Curt Conners' help in figuring everything out. MJ tells them about a dream she's been having, which may be a clue to her disappearance. But Hydro-Man finds them and kidnaps MJ again. Will Spidey be able to find her by following the clues from her dream?