I slutningen af det 24. århundrede og 14 år efter hans pensionering fra Starfleet lever Jean-Luc Picard et roligt liv på sin vingård, Chateau Picard. Da han bliver opsøgt af en mystisk ung kvinde, Dahj, der har brug for hans hjælp, indser han snart, at hun muligvis har personlige forbindelser til hans egen fortid.

Picard begins investigating the mystery of Dahj as well as what her very existence means to the Federation. Without Starfleet's support, Picard is left leaning on others for help, including Dr. Agnes Jurati and an estranged former colleague, Raffi Musiker. Meanwhile, hidden enemies are also interested in where Picard's search for the truth about Dahj will lead.

Completely unaware of her special nature, Soji continues her work and captures the attention of the Borg cube research project’s executive director. After rehashing past events with a reluctant Raffi, Picard seeks others willing to join his search for Bruce Maddox, including pilot and former Starfleet officer Cristóbal Rios.

The crew's journey to Freecloud takes a detour when Picard orders a stop at the planet Vashti, where Picard and Raffi relocated Romulan refugees fourteen years earlier. Upon arrival, Picard reunites with Elnor, a young Romulan he befriended during the relocation. Meanwhile, Narek continues his attempts to learn more about Soji while Narissa's impatience with his lack of progress grows.

The La Sirena crew begins an unpredictable and lively expedition on Freecloud to search for Bruce Maddox. When they learn that Maddox has found himself in a precarious situation, a familiar face offers her assistance.

Picard and Soji transport to the planet Nepenthe, home to some old and trusted friends. As the rest of the La Sirena crew attempt to join them, Picard helps Soji make sense of her recently unlocked memories. Meanwhile, Hugh and Elnor are left on the Borg cube and must face an angered Narissa.

When devastating truths behind the Mars attack are revealed, Picard realizes just how far many will go to preserve secrets stretching back generations, all while the La Sirena crew grapples with secrets and revelations of their own. Narissa directs her guards to capture Elnor, setting off an unexpected chain of events on the Borg cube.

Following an unconventional and dangerous transit, Picard and the crew finally arrive at Soji's home world, Coppelius. However, with Romulan warbirds on their tail, their arrival brings only greater danger as the crew discovers more than expected about the planet’s inhabitants.

A final confrontation on the synthetics’ homeworld, Coppelius pits Picard and his team against the Romulans, as well as the synths who seek to safeguard their existence at all costs.