La saison 1 de Wayne a été diffusée à partir du 16 janvier 2019.

Wayne starts in Brockton, Massachusetts in present day. The titular character "sets out on a dirt bike with his new crush Del to take back the 1979 Pontiac Trans Am that was stolen from his father before he died." The car is in Ocala, Florida. Wayne and Del - and host of oddball characters - go on a road trip to get it back. "It is Wayne and Del against the world."